For quite some time now I am using ESXi 5 update 1 for my lab server and I’m very happy with it. In my lab environment I am not too picky what to run and do not worry about support too much. It’s not production!
One area of concern has been the support for Oracle’s own kernel: UEK or Unbreakable Enterprise Kernel. UEK comes in two editions, one based on 2.6.32, just like Red Hat’s kernel for Red Hat 6. The difference is that you can get UEK/1 (2.6.32.xxx) for Oracle Linux 5.x as well instead of 2.6.18xxx which is otherwise the default.
Oracle’s second iteration of kernel UEK is unsurprisingly named UEK2 and it’s initially based on 3.x but keeps the name to 2.6.39.x for compatibility reasons. UEK2 has some really nice features taken from the Upstream kernel and it is also supported for the Oracle database.